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Debuts Dates of MLB Players
Debuts on May 21
| Player | Year |
| Danny Ainge | 1979 |
| Bill Allison | 1872 |
| Derek Aucoin | 1996 |
| Norm Baker | 1883 |
| Lew Beasley | 1977 |
| Frank Betcher | 1910 |
| Boof Bonser | 2006 |
| Paul Boris | 1982 |
| Al Bradley | 1884 |
| Mace Brown | 1935 |
| Slick Coffman | 1937 |
| Jerry Crider | 1969 |
| Kyle Davies | 2005 |
| Yurendell DeCaster | 2006 |
| Travis Denker | 2008 |
| Frank Eufemia | 1985 |
| Keith Foulke | 1997 |
| Esteban German | 2002 |
| Marv Gudat | 1929 |
| Jesus Guzman | 2009 |
| Diory Hernandez | 2009 |
| Sam Hinds | 1977 |
| Charlie Hudson | 1972 |
| Ray King | 1999 |
| Gene Larkin | 1987 |
| Regis Leheny | 1932 |
| Ron Mahay | 1995 |
| Cristhian Martinez | 2009 |
| Kris Medlen | 2009 |
| Johnny Mitchell | 1921 |
| Balor Moore | 1970 |
| Bill Quarles | 1891 |
| Edgar Ramos | 1997 |
| Paul Rigdon | 2000 |
| Luis Rodriguez | 2005 |
| Matt Ruebel | 1996 |
| Dennis Saunders | 1970 |
| Don Schwall | 1961 |
| Jud Smith | 1893 |
| Dan Spillner | 1974 |
| Craig Stammen | 2009 |
| Kennie Steenstra | 1998 |
| Billy Taylor | 1881 |
| William Van Landingham | 1994 |
| Clay Zavada | 2009 |
| Bart Zeller | 1970 |
